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项目整合精选>>>Rifaximin, alpha-0817185, L-105, Xifaxan, Lumenax, Flonorm, RedActiv, Rifacol, Normix
Rifaximin, alpha-0817185, L-105, Xifaxan, Lumenax, Flonorm, RedActiv, Rifacol, Normix
利福昔明Chemical Name: 4-Deoxy-4'-methylpyrido[1',2'-1,2]imidazo[5,4-c]rifamycin SV
CAS No. 80621-81-4
项目整合开发状态: Launched-1988
项目研究机构: Salix (Orphan Drug), Alfa Wassermann (Originator), Merckle (Licensee), Salix (Licensee), Solochem (Licensee)
合成路线:The reaction of rifamycin S (I) with pyridine perbromide (II) in 2-propanol/chloroform (70/30) mixture at 0 C gives 3-bromorifamicin S (III),which is then condensed with 2-amino-4-methyl-pyridine (IV) at 10 C.The o-quinoniminic compound (V) is then obtained.This compound is finally reduced with ascorbic acid.
📌 参考资料/链接：
参考文献标题:L-105
文献作者:de Angelis,L.
参考来源:Drugs Fut 1982,7(4),260
📄 详细内容
合成路线:The reaction of rifamycin S (I) with pyridine perbromide (II) in 2-propanol/chloroform (70/30) mixture at 0 C gives 3-bromorifamicin S (III),which is then condensed with 2-amino-4-methyl-pyridine (IV) at 10 C.The o-quinoniminic compound (V) is then obtained.This compound is finally reduced with ascorbic acid.
参考文献标题:
文献作者:
参考来源:US 262123
产品链接: CAS No. 80621-81-4››