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项目整合精选>>>Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane
Fenoximone, Enoximone, MDL-17043, RMI-17043, Perfan, Perfane
依诺昔酮Chemical Name: 4-Methyl-5-[p-(methylthio)benzoyl]-4-imidazolin-2-one; 1,3-Dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one
CAS No. 77671-31-9
项目整合开发状态: Launched-1988
项目研究机构: Aventis Pharma (Originator), Lepetit (Originator), Myogen (Licensee)
合成路线:The reaction of 4-(methylthio)benzoic acid (I) with SOCl2 in refluxing benzene gives 4-(methylthio)benzoyl chloride (II),which is then condensed with 1,3-dihydro-4-methyl-2H-imidazol-2-one (III) by means of AlCl3 in hot nitrobenzene.
📌 参考资料/链接：
参考文献标题:4-Aroylimidazol-2-ones
文献作者:Dage,R.C.; Schnettler,R.A.; Grisar,J.M.(Aventis Pharmaceuticals,Inc.)
参考来源:BE 0883856; DE 3021792; FR 2459233; GB 2055364; JP 56005463
📄 详细内容
合成路线:The reaction of 4-(methylthio)benzoic acid (I) with SOCl2 in refluxing benzene gives 4-(methylthio)benzoyl chloride (II),which is then condensed with 1,3-dihydro-4-methyl-2H-imidazol-2-one (III) by means of AlCl3 in hot nitrobenzene.
参考文献标题:RMI-17,043
文献作者:Pento,J.T.; Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1983,8(4),343
产品链接: CAS No. 77671-31-9››