Exemestane, FCE-24304, Aromasin, Nikidess
依西美坦Chemical Name: 6-Methyleneandrosta-1,4-dien-3,17-dione
CAS No. 107868-30-4
项目整合开发状态: Launched-1999
项目研究机构: Pfizer (Originator), National Cancer Institute of Canada (Not Determined)
合成路线:The methylenation of androsta-1,4-dien-17beta-ol-3-one (I) with paraformaldehyde and dimethylamine hydrochloride in isopentanol,at a temperature of at least 130 C,gives 6-methylenandrosta-1,4-diene-17beta-ol-3-one (II).Subsequent oxidation with Jones reagent in acetone,at approx.-10 C,yields exemestane.
📌 参考资料/链接：
参考文献标题:Process for the preparation of methylene derivatives of androsta-1,4-diene-3,17-dione
文献作者:Longo,A.; Lombardi,P.(Pharmacia Corp.)
参考来源:US 4876045
📄 详细内容
合成路线:The methylenation of androsta-1,4-dien-17beta-ol-3-one (I) with paraformaldehyde and dimethylamine hydrochloride in isopentanol,at a temperature of at least 130 C,gives 6-methylenandrosta-1,4-diene-17beta-ol-3-one (II).Subsequent oxidation with Jones reagent in acetone,at approx.-10 C,yields exemestane.
参考文献标题:Exemestane
文献作者:Di Salle,E.; Zaccheo,T.
参考来源:Drugs Fut 1992,17(4),278
产品链接: CAS No. 107868-30-4››