Ecabamide, Ecabapide, DQ-2511, Muralis
依卡派特Chemical Name: 3-[[2-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-2-oxoethyl]amino]-N-methylbenzamide
CAS No. 104775-36-2
项目整合开发状态: Phase III
项目研究机构: Daiichi Pharmaceutical (Originator)
合成路线:The reaction of 3-nitrobenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II),which by reaction with methylamine in chloroform is converted to the methylamide (III).The reduction of (III) with H2 over RaNi in methanol yields the 3-amino-N-methylbenzamide (IV),which is finally condensed with 2-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (V) by means of NaI and CaCO3 in hot DMF.
📌 参考资料/链接：
参考文献标题:Aminobenzamide derivatives
文献作者:Miki,T.; Asano,M.; Hosokami,T.(Daiichi Seiyaku Co.,Ltd.)
参考来源:EP 0185368
📄 详细内容
合成路线:The reaction of 3-nitrobenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II),which by reaction with methylamine in chloroform is converted to the methylamide (III).The reduction of (III) with H2 over RaNi in methanol yields the 3-amino-N-methylbenzamide (IV),which is finally condensed with 2-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide (V) by means of NaI and CaCO3 in hot DMF.
参考文献标题:DQ-2511
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(7),620
产品链接: CAS No. 104775-36-2››