网站主页>>>项目整合精选>>>项目整合精选>>>Etanidazole, NSC-301467, DuP-435, SR-2508, SP-2508, Radinyl

Etanidazole, NSC-301467, DuP-435, SR-2508, SP-2508, Radinyl

依他硝唑Chemical Name: N-(2-Hydroxyethyl)-2-nitroimidazole-1-acetamide
CAS No. 22668-01-5
项目整合开发状态: Phase III
项目研究机构: National Cancer Institute (Originator), SRI (Originator), Amersham (Licensee), Shire Pharmaceuticals (Licensee)
合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III),which is then treated with ethanolamine (IV) in methanol.

合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in methanol - DMF at 150 C gives methyl 2-nitro-1-imidazolylacetate (III),which is then condensed with benzylamine (IV) in methanol.
📌 参考资料/链接：
参考文献标题:Novel imidazole derivs.and a process for the manufacture thereof
文献作者:Beaman,A.G.; Duschinsky,R.; Tautz,W.P.(F.Hoffmann-La Roche AG)
参考来源:GB 1138529

📄 详细内容


合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III),which is then treated with ethanolamine (IV) in methanol.

参考文献标题:2-Nitroimidazoles
文献作者:Beaman,A.G.; Duschinsky,R.; Tautz,W.P.(F.Hoffmann-La Roche AG)
参考来源:US 3679698


合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III),which is then treated with ethanolamine (IV) in methanol.

参考文献标题:Nitroimidazoles of low toxicity and high activity as radiosensitizers of hypoxic tumor cells
文献作者:Lee,W.W.; Brown,J.M.; Martinez,A.P.; Cory,M.J.(US Department of Health & Human Services)
参考来源:US 4371540


合成路线:The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III),which is then treated with ethanolamine (IV) in methanol.
参考文献标题:Etanidazole
文献作者:Castar,J.; Robinson,C.
参考来源:Drugs Fut 1995,20(8),772


产品链接: CAS No. 22668-01-5››
← 返回产品列表