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项目整合精选>>>Zotepine, FR-1314, Engramon, Zoleptil, Nipolept, Lodopin
Zotepine, FR-1314, Engramon, Zoleptil, Nipolept, Lodopin
佐替平Chemical Name: 8-Chloro-10-(2-dimethylaminoethoxy)dibenzo[b,f]thiepine
CAS No. 26615-21-4
项目整合开发状态: Launched-1982
项目研究机构: Fujisawa (Originator), Abbott (Licensee), Aventis Pharma (Licensee), Orion Corp. (Licensee)
合成路线:Compound can be prepared in two different ways:1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C.2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.
📌 参考资料/链接：
参考文献标题:Tricyclic enol ether compounds
文献作者:Umio,S.; et al.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:DE 1907670; FR 2002064; GB 1247067; NL 6902489; US 3704245
📄 详细内容
合成路线:Compound can be prepared in two different ways:1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C.2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.
参考文献标题:Zotepine
文献作者:Blancafort,P.; Serradell,M.N.; Hillier,K.; Castar,J.
参考来源:Drugs Fut 1979,4(10),758
合成路线:Compound can be prepared in two different ways:1) By condensation of 8-chlorodibenzo[b,f]thiepin-10(11H)-one (I) with 2-dimethylaminoethyl chloride (II) by means of NaH in benzene - DMF at 60 C.2) By condensation of 8-chloro-10-(2-chloroethoxy)dibenzo[b,f]thiepin (III) with dimethylamine.
参考文献标题:
文献作者:Umio,S.; Ueta,I.
参考来源:JP 7235439
产品链接: CAS No. 26615-21-4››