合成路线:The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II),which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene,followed by dilution with ethanol and reduction with sodium cyanoborohydride.
参考文献标题:Polycyclic biocidal cpds.,their synthesis,formulations containing them
文献作者:Bair,K.W.(Glaxo Wellcome plc)
参考来源:EP 0182609; ES 8706102; ES 8802415; ES 8802481
合成路线:The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II),which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene,followed by dilution with ethanol and reduction with sodium cyanoborohydride.
参考文献标题:2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators.An examination of the effects of aromatic ring variation on antitumor activity and DNA binding
文献作者:Bair,K.W.; Andrews,C.W.; Tuttle,R.L.; Knick,V.C.; Cory,M.; McKee,D.D.
参考来源:J Med Chem 1991,34(7),1983-90
合成路线:The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II),which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene,followed by dilution with ethanol and reduction with sodium cyanoborohydride.
参考文献标题:Crisnatol Mesylate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1993,18(3),216
产品链接: CAS No. 96389-69-4›› 产品链接: CAS No.96389-68-3››