合成路线:The methylation of 2'-O,N-bis(benzyloxycarbonyl)-N-demethylerythromycin A (I) with methyl iodide and KOH or NaHI in DMSO-dimethoxyethane gives the 6-O-methyl derivative (II),which is deprotected by hydrogenation with H2 over Pd/C in ethanol acetic acid affording 6-O-methyl-N-demethylerythromycin A (III).Finally,this compound is methylated with formaldehyde under reductive conditions (H2-Pd/C) in ethanol/acetic acid.
参考文献标题:Method for preparing 6-O-methyl-2'-O,N-bis(benzyloxycarbonyl)-N-dimethylerythromycin a
文献作者:Adachi,T.; Kikugawa,Y.; Morimoto,S.; Sota,K.; Takahashi,Y.; Watanabe,Y.(Taisho Pharmaceutical Co.,Ltd.)
参考来源:EP 0147062
合成路线:The methylation of 2'-O,N-bis(benzyloxycarbonyl)-N-demethylerythromycin A (I) with methyl iodide and KOH or NaHI in DMSO-dimethoxyethane gives the 6-O-methyl derivative (II),which is deprotected by hydrogenation with H2 over Pd/C in ethanol acetic acid affording 6-O-methyl-N-demethylerythromycin A (III).Finally,this compound is methylated with formaldehyde under reductive conditions (H2-Pd/C) in ethanol/acetic acid.
参考文献标题:6-O-Methylerythromycin A
文献作者:Serradell,M.N.; Castar,R.M.; Castar,J.
参考来源:Drugs Fut 1987,12(10),952
合成路线:The methylation of 2'-O,N-bis(benzyloxycarbonyl)-N-demethylerythromycin A (I) with methyl iodide and KOH or NaHI in DMSO-dimethoxyethane gives the 6-O-methyl derivative (II),which is deprotected by hydrogenation with H2 over Pd/C in ethanol acetic acid affording 6-O-methyl-N-demethylerythromycin A (III).Finally,this compound is methylated with formaldehyde under reductive conditions (H2-Pd/C) in ethanol/acetic acid.
参考文献标题:Chemical modification of erythromycins.1.Synthesis and antibacterial activity of 6-O-methylerythromycins A
文献作者:Morimoto,S.; Takahashi,Y.; Watanabe,Y.; Omura,S.
参考来源:J Antibiot 1984,37(2),187-189
产品链接: CAS No. 81103-11-9››