Fentiapril, Rentiapril, DE-040, SA-446
伦唑普利Chemical Name: (2R,4R)-2-(2-Hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidinecarboxylic acid; (2R,4R)-2-(Hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-4-thiazolidinecarboxylic acid
CAS No. 80830-42-8
项目整合开发状态: Phase III
项目研究机构: Santen (Originator)
合成路线:The condensation of 2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (I) with S-benzoyl-3-mercaptopropanoyl chloride (II) by means of triethylamine in acetone gives 3-(S-benzoyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (III),which is debenzylated by a treatment with NH3.
📌 参考资料/链接：
参考文献标题:SA-446
文献作者:Sneddon,J.M.; Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(1),36
📄 详细内容
合成路线:The condensation of 2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (I) with S-benzoyl-3-mercaptopropanoyl chloride (II) by means of triethylamine in acetone gives 3-(S-benzoyl-3-mercaptopropanoyl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (III),which is debenzylated by a treatment with NH3.
参考文献标题:
文献作者:
参考来源:BE 0875365
产品链接: CAS No. 80830-42-8››