Vadocaine hydrochloride, K-242-HCl, ORK-242-HCl
伐多卡因Chemical Name: 2',4'-Dimethyl-6'-methoxy-3-(2-methylpiperidino)propionanilide hydrochloride; 3-(2-Methylpiperidino)-N-(2,4-dimethyl-6-methoxyphenyl)propionamide hydrochloride
CAS No. 72005-58-4 (free base)
项目整合开发状态: Phase II
项目研究机构: Orion Corp. (Originator)
合成路线:The condensation of 3-chloropropionyl chloride (I) with 2,4 dimethyl-6 methoxyaniline (II) by means of sodium acetate in glacial acetic acid gives 3-chloro-N-(2,4-dimethyl-6-methoxyphenyl)propionamide (III),which is condensed with 2-methylpiperidine (IV) in refluxing anhydrous benzene.
📌 参考资料/链接：
参考文献标题:Novel anilides,their process of preparation and t
文献作者:Kaila,J.O.W.; Honkanen,E.J.; Alberty,J.E.; Hukki,J.J.(Orion Corporation)
参考来源:BE 0873957; US 4353914
📄 详细内容
合成路线:The condensation of 3-chloropropionyl chloride (I) with 2,4 dimethyl-6 methoxyaniline (II) by means of sodium acetate in glacial acetic acid gives 3-chloro-N-(2,4-dimethyl-6-methoxyphenyl)propionamide (III),which is condensed with 2-methylpiperidine (IV) in refluxing anhydrous benzene.
参考文献标题:Vadocaine hydrochloride
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(10),936
产品链接: CAS No. 72005-58-4››