合成路线:The condensation of 6-bromohexanoic acid (I) with triphenylphosphine in refluxing acetonitrile gives the corresponding phosphonium salt (III),which is submitted to a Wittig condensation with phenyl 3-pyridyl ketone (IV) by means of NaH in DMSO,yielding a mixture of the title product and its (Z)-isomer (V).This mixture of isomers is separated by fractional crystallization or HPLC and the isomeric compound (V) is treated with refluxing aqueous 25% HBr to perform its isomerization to CV-415.
参考文献标题:CV-4151
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(3),183
合成路线:The condensation of 6-bromohexanoic acid (I) with triphenylphosphine in refluxing acetonitrile gives the corresponding phosphonium salt (III),which is submitted to a Wittig condensation with phenyl 3-pyridyl ketone (IV) by means of NaH in DMSO,yielding a mixture of the title product and its (Z)-isomer (V).This mixture of isomers is separated by fractional crystallization or HPLC and the isomeric compound (V) is treated with refluxing aqueous 25% HBr to perform its isomerization to CV-415.
参考文献标题:Thromboxane synthetase inhibitors (TXSI).Design,synthesis,and evaluation of a novel series of omega-pyridilalkenoic acids
文献作者:Kato,K.; Ohkawa,S.; Terao,S.; Terashita,Z.; Nishikawa,K.
参考来源:J Med Chem 1985,28(3),287-294
产品链接: CAS No. 89667-40-3››