Ipsapirone, Bay-q-7821(hydrochloride), TVX-Q-7821(hydrochloride)
伊沙匹隆 伊沙匹隆 Chemical Name: 2-[4-[4-(2-Pyrimidinyl)piperazinyl]butyl]benzisothiazol-3(2H)-one 1,1-dioxide
CAS No. 95847-70-4, 92589-98-5 (monoHCl)
项目整合开发状态: Phase III
项目研究机构: Troponwerke (Originator)
合成路线:The reaction of benzoisothiazole-3(2H)-one-1,1-dioxide (I) with 1,4-dibromobutane (II) by means of NaH in DMF gives 2-(4-bromobutyl)benzoisothiazole-3(2H)-one-1,1-dioxide (III),which is then condensed with 1-(2 pyrimidinyl)piperazine (IV) by means of K2CO3 in refluxing chlorobenzene.
📌 参考资料/链接：
参考文献标题:2-pyrimidinyl-1-piperazine derivatives,proceses for their preparation and medicaments containing them
文献作者:Seidel,P.-R.; Horstmann,H.; Traber,J.; Dompert,W.; Glaser,T.; Schuurman,T.(Troponwerke GmbH & Co KG)
参考来源:EP 0129128; JP 60023373; US 4818756; US 4937343; US 4988809
📄 详细内容
合成路线:The reaction of benzoisothiazole-3(2H)-one-1,1-dioxide (I) with 1,4-dibromobutane (II) by means of NaH in DMF gives 2-(4-bromobutyl)benzoisothiazole-3(2H)-one-1,1-dioxide (III),which is then condensed with 1-(2 pyrimidinyl)piperazine (IV) by means of K2CO3 in refluxing chlorobenzene.
参考文献标题:Ipsapirone
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(7),565
产品链接: CAS No. 95847-70-4›› 产品链接: CAS No.92589-98-5››