Ilepcimide, Antiepilepsirine
伊来西胺 3-(1,3-苯并二氧戊环-5-基)-1-(1-哌啶基)-2-丙烯-1-酮 Chemical Name: (E)-1-[3,4-(Methylenedioxy)cinnamoyl]piperidine; (E)-1-[3-(1,3-Benzodioxol-5-yl)-1-oxo-2-propenyl]piperidine
CAS No. 82857-82-7, 23434-86-8 (undefined isomer)
项目整合开发状态: Phase III
项目研究机构: Beijing Medical University (Originator)
合成路线:3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene.The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.
📌 参考资料/链接：
参考文献标题:Structure-anticonvulsant activity relationships of some cinnamamides of substituted aromatic ring
文献作者:Wang,S.; Li,R.; Liu,W.; et al.
参考来源:Acta Pharm Sin 1986,21(7),542-5
📄 详细内容
合成路线:3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene.The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.
参考文献标题:Pharmacological study of tablettae antiepilepticae I.Its effect on the CNS
文献作者:Pei,Y.; Li,J.; Cai,Z.; Zhang,B.; Ku,B.
参考来源:Nat Med J China 1978,58(4),216-9
合成路线:3,4-Methylenedioxycinnamic acid (I) is transformed into the corresponding acid chloride (II) by treatment with oxalyl chloride in benzene.The acid chloride is then converted without purification into antiepilepsirine by treatment with piperidine in benzene.
参考文献标题:ANTIEPILEPSIRINE
文献作者:Ruyun,J.
参考来源:Drugs Fut 1990,15(4),331
产品链接: CAS No. 82857-82-7›› 产品链接: CAS No.23434-86-8››