Tamolarizine hydrochloride, NC-1100
他莫利嗪Chemical Name: (?-1-(3,4-Dimethoxyphenyl)-2-(4-diphenylmethyl-1-piperazinyl)ethanol dihydrochloride; (?-alpha-(3,4-Dimethoxyphenyl)-4-(diphenylmethyl)-1-piperazineethanol dihydrochloride
CAS No. 128229-52-7 (free base), 93035-32-6 (free base, non-specified stereoch.), 93035-33-7 (undefined stereoch.)
项目整合开发状态: Phase II
项目研究机构: Nippon Chemiphar (Originator)
合成路线:The reaction of 1-(diphenylmethyl)piperazine (I) with 3,4-dimethoxyphenacyl bromide (II) by means of triethylamine in isopropanol gives alpha-[4-(diphenylmethyl)-1-piperazinyl]-3,4-dimethoxyacetophenone (III),which is then reduced with NaBH4 in ethanol-CHCl3.
📌 参考资料/链接：
参考文献标题:New piperazine derivs.,their salts and pharmaceuticals for improving cerebral circulation
文献作者:Mitsuo,M.(Nippon Chemiphar Co.,Ltd.)
参考来源:DE 3326148; ES 8603449
📄 详细内容
合成路线:The reaction of 1-(diphenylmethyl)piperazine (I) with 3,4-dimethoxyphenacyl bromide (II) by means of triethylamine in isopropanol gives alpha-[4-(diphenylmethyl)-1-piperazinyl]-3,4-dimethoxyacetophenone (III),which is then reduced with NaBH4 in ethanol-CHCl3.
参考文献标题:NC-1100
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(4),334
产品链接: CAS No. 128229-52-7›› 产品链接: CAS No.93035-32-6››