合成路线:This compound can be obtained in tvvo different ways:1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (?-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II).Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B).2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).
参考文献标题:
文献作者:Los,M.A.
参考来源:BE 0858897
合成路线:This compound can be obtained in tvvo different ways:1) The reaction of 3-bromophthalide (A) with 5-methoxy-2-methyl-1H-indole-3-acetic acid (I) previously salified with triethylamine in refluxing acetone gives (?-1,3-dihydro-3-oxo-1-isobenzofuranyl-5-methoxy-2-methyl-1H-indole-3-acetate (II).Compound (II) is salified with sodium hydride and then acylated with p-chlorobenzoyl chloride (B).2) By condensation of the organic salt of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (III) with 3-bromophthalide (A).
参考文献标题:Talmetacin
文献作者:Torriani,H.
参考来源:Drugs Fut 1982,7(11),825
产品链接: CAS No. 67489-39-8››