合成路线:The methylation of 4,5-dihydroorotic acid benzyl ester (I) with methyl iodide gives the corresponding 1-methyl derivative (II),which is debenzylated by hydrogenolysis with H2 over Pd/C yielding (S)-1-methyl-4,5-dihydroorotic acid (III).Finally,this compound is condensed with L-histidyl-L-prolinamide (IV) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (HONSU) in DMF.
参考文献标题:Dihydroorotic acid derivs.and process for their preparation
文献作者:Sugano,H.; Ishida,R.; Yamamura,M.(Tanabe Seiyaku Co.,Ltd.)
参考来源:JP 1986033197
合成路线:The methylation of 4,5-dihydroorotic acid benzyl ester (I) with methyl iodide gives the corresponding 1-methyl derivative (II),which is debenzylated by hydrogenolysis with H2 over Pd/C yielding (S)-1-methyl-4,5-dihydroorotic acid (III).Finally,this compound is condensed with L-histidyl-L-prolinamide (IV) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (HONSU) in DMF.
参考文献标题:Therapeutic agent for central nervous system disorders
文献作者:Sugano,H.; Ishida,R.; Yamamura,M.(Tanabe Seiyaku Co.,Ltd.)
参考来源:JP 1987234029
合成路线:The methylation of 4,5-dihydroorotic acid benzyl ester (I) with methyl iodide gives the corresponding 1-methyl derivative (II),which is debenzylated by hydrogenolysis with H2 over Pd/C yielding (S)-1-methyl-4,5-dihydroorotic acid (III).Finally,this compound is condensed with L-histidyl-L-prolinamide (IV) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (HONSU) in DMF.
参考文献标题:Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety
文献作者:Suzuki,M.; Sugano,H.; Matsumoto,K.; Yamamura,M.; Ishida,R.
参考来源:J Med Chem 1990,33(8),2130-37
合成路线:The methylation of 4,5-dihydroorotic acid benzyl ester (I) with methyl iodide gives the corresponding 1-methyl derivative (II),which is debenzylated by hydrogenolysis with H2 over Pd/C yielding (S)-1-methyl-4,5-dihydroorotic acid (III).Finally,this compound is condensed with L-histidyl-L-prolinamide (IV) by means of dicyclohexylcarbodiimide (DCC) and N-hydroxysuccinimide (HONSU) in DMF.
参考文献标题:TA-0910
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1991,16(2),127
产品链接: CAS No. 103300-74-9››