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项目整合精选>>>Talaporfin sodium, Mono-L-aspartyl chlorin e6, LS-11, ME-2906, NPe6, Laserphyrin
Talaporfin sodium, Mono-L-aspartyl chlorin e6, LS-11, ME-2906, NPe6, Laserphyrin
他拉泊芬钠 他拉泊芬Chemical Name: N-[2-[(2S,3S)-7-Carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydro-21H,23H-porphin-5-yl]acetyl]-L-aspartic acid tetrasodium salt
CAS No. 220201-34-3, 220201-39-8 (deleted CAS), 110230-98-3 (free acid)
项目整合开发状态: Launched-2004
项目研究机构: Nippon Petrochemicals (Originator), Light Sciences (Licensee), Meiji Seika (Licensee)
合成路线:Coupling of chlorin e6 (I) with L-aspartic acid di-t-butyl ester (II) in the presence of DCC gave rise to amide (III).The ester groups were then hydrolyzed using a 1 M solution of KOH.
📌 参考资料/链接：
参考文献标题:Tetrapyrrole carboxylic acid derivs.for diagnosis and/or therapy of arthritis
文献作者:Aizawa,K.; Kuroiwa,Y.(Nippon Petrochemicals Co.,Ltd.)
参考来源:EP 0629409; US 5430051
📄 详细内容
合成路线:Coupling of chlorin e6 (I) with L-aspartic acid di-t-butyl ester (II) in the presence of DCC gave rise to amide (III).The ester groups were then hydrolyzed using a 1 M solution of KOH.
参考文献标题:The structures of mono-L-aspartyl chlorin e6 and its related compounds
文献作者:Gomi,S.; et al.
参考来源:Heterocycles 1998,48(11),2231
产品链接: CAS No. 220201-34-3›› 产品链接: CAS No.110230-98-3››