Tazasubrate, EMD-34853
他扎贝特Chemical Name: (?-2-Phenyl-2-[(6-ethoxy-2-benzothiazolyl)thio]propionic acid; (?-alpha-[(6-Ethoxy-2-benzothiazolyl)thio]-alpha-methylphenylacetic acid; (?-alpha-[(Ethoxy-2-benzothiazolyl)thio]hydratropic acid
CAS No. 79071-15-1
项目整合开发状态: Biological Testing
项目研究机构: Merck KGaA (Originator)
合成路线:This compound can be obtained by two different ways:1) The condensation of 2-mercapto-6-ethoxybenzothiazole (I) with 2-bromo-2-phenylpropionate (II) by means of sodium ethoxide in refluxing ethanol gives 2-phenyl-2-[(6-ethoxy-2-benzothiazoyl)thio]propionate (III),which is then hydrolyzed with KOH in ethanol.2) By condensation of 2-chloro-6-ethoxybenzothiazole (IV) with 2-mercapto-2-phenylpropionic acid (V) by means of NaOH in refluxing butanol.
📌 参考资料/链接：
参考文献标题:Tazasubrate
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(9),667
📄 详细内容
合成路线:This compound can be obtained by two different ways:1) The condensation of 2-mercapto-6-ethoxybenzothiazole (I) with 2-bromo-2-phenylpropionate (II) by means of sodium ethoxide in refluxing ethanol gives 2-phenyl-2-[(6-ethoxy-2-benzothiazoyl)thio]propionate (III),which is then hydrolyzed with KOH in ethanol.2) By condensation of 2-chloro-6-ethoxybenzothiazole (IV) with 2-mercapto-2-phenylpropionic acid (V) by means of NaOH in refluxing butanol.
参考文献标题:Benzothiazole derivatives and pharmaceutical formulations containing them
文献作者:Doll,T.; Scacht,E.; Radunz,H.E.; Schulze,E.
参考来源:DE 2950095; EP 0030632; ES 8203867; JP 56092881; US 4294839
产品链接: CAS No. 79071-15-1››