合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:Phthalidyl 2-(3'-trifluoromethylanilino)pyridine-3-caboxylalate and process for its preparation
文献作者:
参考来源:AR 209858; GB 1553171
合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:Nouveaux esters d'acides ph閚yl- et pyridine-3-carboxylique et proc閐?premettant leur pr閜aration
文献作者:
参考来源:BE 0858864
合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:Procedimiento para la obtenci髇 de nuevos 閟terees de 醕idos fenil- y piridin-3-carbox韑icos sustituidos
文献作者:
参考来源:ES 474566
合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:
文献作者:
参考来源:US 879749
合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:
文献作者:
参考来源:GB 381578
合成路线:Two different ways to obtain talniflumate were developed:The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I).The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV),which is then treated with 3-trifluoromethylaniline (V).
参考文献标题:Acidos anilino nicot韓ico y N-arilantran韑icos convenientemente sustituidos
文献作者:Boned,J.; Los,M.; Piccinali,C.
参考来源:VII Latinoamerican Congress Pharmacology 1978,
产品链接: CAS No. 66898-62-2››