DAA-1097

乙酰胺,N-(4-氯-2-苯氧基苯基)-N-[[2-(1-甲基氧基)苯基]甲基]-Chemical Name: N-(4-Chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide
CAS No. 220551-79-1
项目整合开发状态: Preclinical
项目研究机构: Nihon Nohyaku (Originator), Taisho (Originator)
合成路线:4-Chloro-2-phenoxyaniline (I) was acylated with acetyl chloride and triethylamine to afford acetamide (II).Alkylation of the amide N of (II) by 2-isopropoxybenzyl chloride (III) in the presence of NaH provided the target tertiary amide.

合成路线:5-Fluoro-2-phenoxyaniline (I) was acylated with acetyl chloride and triethylamine to afford acetamide (II).Alkylation of the amide N by 2,5-dimethoxybenzyl chloride (III) in the presence of NaH provided the target tertiary amide.