Ebrotidine, FI-3542, Ebrocit
乙溴替丁Chemical Name: (E)-N-[2-[2-(Diaminomethyleneamino)thiazol-4-ylmethylsulfanyl]ethylaminomethylene]-4-bromobenzenesulfonamide
CAS No. 100981-43-9
项目整合开发状态: Withdrawn-1998
项目研究机构: Ferrer (Originator), Robert Labs. (Not Determined)
合成路线:The reaction of 4-bromobenzenesulfonamide (I) with triethyl orthoformate (II) at 110 C gives the corresponding formimidate (III),which is then condensed with 2-[4-[[(2-aminoethyl)thio]methyl]-2-thiazolyl]guanidine (IV) in methanol.
📌 参考资料/链接：
参考文献标题:Sulfonamidines,a process for preparing them and pharmaceutical compositions containing them
文献作者:Foguet,R.; Anglada,L.; Castell? J.M.; Sacrist醤,A.; Ortiz,J.A.(Ferrer Internacional SA)
参考来源:EP 0159012; JP 1986000073; US 4728655
📄 详细内容
合成路线:The reaction of 4-bromobenzenesulfonamide (I) with triethyl orthoformate (II) at 110 C gives the corresponding formimidate (III),which is then condensed with 2-[4-[[(2-aminoethyl)thio]methyl]-2-thiazolyl]guanidine (IV) in methanol.
参考文献标题:Ebrotidine
文献作者:Castell? J.M.; Sacrist醤,A.; Ortiz,J.A.
参考来源:Drugs Fut 1996,21(2),135
合成路线:The reaction of 4-bromobenzenesulfonamide (I) with triethyl orthoformate (II) at 110 C gives the corresponding formimidate (III),which is then condensed with 2-[4-[[(2-aminoethyl)thio]methyl]-2-thiazolyl]guanidine (IV) in methanol.
参考文献标题:Inhibitors of gastric acid secretion: N-Sulphonyl formamidines in a series of new histamine H2-receptor antagonists
文献作者:Anglada,L.; M醨quez,M.; Sacrist醤,A.; Ortiz,J.A.
参考来源:Eur J Med Chem 1988,2397-100
产品链接: CAS No. 100981-43-9››