Irampanel hydrochloride, BIIR-561-CL

乙氨酸,N-二甲基-2-[2-(3-苯基-1,2,4-氧二氮醇-5-基)苯氧基]-,单盐酸盐 N,N-二甲基-2-[2-(3-苯基-1,2,4-恶二唑-5-基)苯氧基]-乙胺 Chemical Name: N,N-Dimethyl-N-[2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethyl]amine hydrochloride
CAS No. 206260-34-6, 206260-33-5 (free base)
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The condensation between benzamidoxime (I) and methyl salicylate (II) in the presence of NaOEt under microwave irradiation generated oxadiazole (III).Subsequent alkylation of the hydroxyl group of (III) with dimethylaminoethyl chloride and NaH in dioxan produced the target aminoethyl ether,which was finally isolated as the corresponding hydrochloride salt.