CAM
乙基O-(N-(4-羧苯基)氨甲酰)麦钴苯甲酸酯Chemical Name: Ethyl O-[N-(p-carboxyphenyl)carbamoyl]mycophenolate; Ethyl 5-[4'-[N-(p-carboxyphenyl)carbamoyloxy]-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl]-3-methyl-3-penten-1-carboxylate; 4-[[[[5-(6-Ethoxy-3-methyl-6-oxo-2-hexenyl)-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl]oxy]carbonyl]amino]benzoic acid
CAS No. 40449-96-5 ((E)-isomer)
项目整合开发状态: Preclinical
项目研究机构: Ajinomoto (Originator), Chugai (Originator)
合成路线:The reaction of ethyl mycophenolate (I) with phosgene in benzene gives ethyl 5-(4'-chloroformyloxy-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl)-3-methyl-3-penten-1-carboxylate (II),which is then condensed with p-aminobenzoic acid (III) in THF.
📌 参考资料/链接：
参考文献标题:CAM
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.; Hillier,K.
参考来源:Drugs Fut 1981,6(5),272
📄 详细内容
合成路线:The reaction of ethyl mycophenolate (I) with phosgene in benzene gives ethyl 5-(4'-chloroformyloxy-6'-methoxy-7'-methyl-3'-oxo-5'-phthalanyl)-3-methyl-3-penten-1-carboxylate (II),which is then condensed with p-aminobenzoic acid (III) in THF.
参考文献标题:
文献作者:Mori,T.; et al.
参考来源:DE 2237549
产品链接: CAS No. 40449-96-5››