Technetium (99mTc) exametazime, [99mTc]-HMPAO, HMPAO-[99mTc], Ceretec
依沙美肟 钛-99Tc,[[3,3'-[(2,2-二甲基-1,3-丙二二基)di(亚氨基-kN)]双[2-丁酮] di(oximato-kN)](3-)]oxo-, (SP-5-15)-(9CI)Chemical Name: [[(?-(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium-99Tc
CAS No. 100551-63-1 (ligand), 105613-48-7 (ligand no stereoch.), 100504-35-6 (undefined stereoch.)
项目整合开发状态: Launched-1989
项目研究机构: Amersham (Originator)
合成路线:Condensation of 2,3-butanedione monooxime (I) with 2,2,-dimethyl-1,3-propanediamine (II) affords the bis-imine adduct (III).Subsequent reduction of the imine functions of (III) using NaBH4 in EtOH gives rise to a mixture of the meso-diamine (IV) and the racemic d,l-isomers (V).Separation of this mixture is achieved by either HPLC or fractional crystallization from acetonitrile and then from ethyl acetate.The target 99mtechnetium complex is prepared in situ by reduction of a solution of 99mTc-pertechnetate with stannous tartrate in the presence of the diamino dioxime ligand (V).
📌 参考资料/链接：
参考文献标题:Complexes of technetium-99m with propylene amine oximes
文献作者:Nowotnik,D.P.; Canning,L.R.; Neirinckx,R.D.; Piper,I.M.(Amersham plc)
参考来源:EP 0194843; JP 1986225159; US 4789736
📄 详细内容
合成路线:Condensation of 2,3-butanedione monooxime (I) with 2,2,-dimethyl-1,3-propanediamine (II) affords the bis-imine adduct (III).Subsequent reduction of the imine functions of (III) using NaBH4 in EtOH gives rise to a mixture of the meso-diamine (IV) and the racemic d,l-isomers (V).Separation of this mixture is achieved by either HPLC or fractional crystallization from acetonitrile and then from ethyl acetate.The target 99mtechnetium complex is prepared in situ by reduction of a solution of 99mTc-pertechnetate with stannous tartrate in the presence of the diamino dioxime ligand (V).
参考文献标题:Separation of the stereoisomers of hexamethyl-propyleneamine oxime (HM-PAO) by high-performance liquid chromatography
文献作者:Nowotnik,D.P.; et al.
参考来源:J Liq Chromatogr 1995,18(4),673
合成路线:Condensation of 2,3-butanedione monooxime (I) with 2,2,-dimethyl-1,3-propanediamine (II) affords the bis-imine adduct (III).Subsequent reduction of the imine functions of (III) using NaBH4 in EtOH gives rise to a mixture of the meso-diamine (IV) and the racemic d,l-isomers (V).Separation of this mixture is achieved by either HPLC or fractional crystallization from acetonitrile and then from ethyl acetate.The target 99mtechnetium complex is prepared in situ by reduction of a solution of 99mTc-pertechnetate with stannous tartrate in the presence of the diamino dioxime ligand (V).
参考文献标题:Development of a 99Tcm-labelled radiopharmaceutical for cerebral blood flow imaging
文献作者:Nowotnik,D.P.; Canning,L.R.; Cumming,S.A.; Harrison,R.C.; Higley,B.; Nechvatal,G.; Pickett,R.D.; Piper,I.M.; Bayne,V.J.; Forster,A.M.; et al.
参考来源:Nucl Med Commun 1985,6(9),499
产品链接: CAS No.105613-48-7›› 产品链接: CAS No.100504-35-6››