Epalrestat, Ono-2235, Kinedak
依帕司他Chemical Name: (Z,E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxothiazolidine-3-acetic acid; (Z,E)-3-(Carboxymethyl)-5-(beta-methylcinnamylidene)rhodanine; (Z,E)-5-(beta-Methylcinnamylidene)-4-oxo-2-thioxothiazolidine-3-acetic acid
CAS No. 82159-09-9
项目整合开发状态: Launched-1992
项目研究机构: Ono (Originator)
合成路线:By condensation of beta-methylcinnamylaldehyde (I) with 3-(carboxymethyl)rhodanine (II) by means of sodium acetate in refluxing acetic acid.
📌 参考资料/链接：
参考文献标题:Rhodanine derivs.,process for their preparation,
文献作者:Hiroshi,T.; Tetsuya,M.; Takeshi,M.; Akio,A.; Masanori,K.; Fumio,H.; Tadao,T.; Masaki,H.(Ono Pharmaceutical Co.,Ltd.)
参考来源:EP 0047109; US 4464382
📄 详细内容
合成路线:By condensation of beta-methylcinnamylaldehyde (I) with 3-(carboxymethyl)rhodanine (II) by means of sodium acetate in refluxing acetic acid.
参考文献标题:Epalrestat
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1987,12(4),336
产品链接: CAS No. 82159-09-9››