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项目整合精选>>>Mitoguazone, Win-10708-2, NSC-30609(acetate), NSC-32946(diHCl), MGBG, Methyl-GAG, Zyrkamine
Mitoguazone, Win-10708-2, NSC-30609(acetate), NSC-32946(diHCl), MGBG, Methyl-GAG, Zyrkamine
丙脒腙 米托瓜腙(二盐酸盐) Chemical Name: 2,2'-(1-Methyl-1,2-ethanediylidene)bishydrazinecarboximidamide; 1,1'-[(Methylethanediylidene)dinitrilo]diguanidine; Methylglyoxal bis-amidinohydrazone; Methylglyoxal bis-guanylhydrazone
CAS No. 459-86-9, 7059-23-6 (diHCl)
项目整合开发状态: Phase III
项目研究机构: National Cancer Institute (Originator), Ilex Oncology (Licensee), Sanofi-Aventis (Licensee)
合成路线:The oxidation of acetone (I) with butyl nitrite (II) with a catalytic amount of HCl gives methylglyoxal 1-oxime (III),which is then condensed with aminoguanidine (IV) in hot water acidified with HCl.
📌 参考资料/链接：
参考文献标题:Mitoguazone
文献作者:Serradell,M.N.; Eastland,G.W.; Castar,J.
参考来源:Drugs Fut 1984,9(3),199
📄 详细内容
合成路线:The synthesis of [14C]-mitoguazone has been reported:The methylation of [14C]-labeled potassium acetate (I) with dimethyl sulfate in HMPT gives the corresponding ester (II),which by reaction with the sodium salt of dimethylsulfoxide (III) in DMSO affords the hemithioketal (IV).Finally,this compound is condensed with aminoguanidine (V) in DMSO/water.
参考文献标题:Convenient synthesis of [2-C-14]-methylglyoxal bis(guanylhydrazone),[C-14]-mitoguazone
文献作者:Burgos,A.; Ellames,G.J.
参考来源:J Label Compd Radiopharm 1995,36(1),93
合成路线:The oxidation of acetone (I) with butyl nitrite (II) with a catalytic amount of HCl gives methylglyoxal 1-oxime (III),which is then condensed with aminoguanidine (IV) in hot water acidified with HCl.
参考文献标题:Antiviral compounds.IX.Synthesis and anti-influenza virus activity of bis-amidinohydrazones of glyoxal and methylglyoxal
文献作者:Nagaki,D.; Nishimura,T.; Hasegawa,K.; Toku,H.; Sakaguchi,H.; Yamazaki,C.
参考来源:Kitasato Arch Exp Med 1975,48(4),171-181
产品链接: CAS No. 459-86-9›› 产品链接: CAS No.7059-23-6››