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项目整合精选>>>Disoprofol, Propofol, AM-149(New formulation), ZD-0859, ICI-35868, Ampofol, Propofol IDD-D, Disoprivan, Diprivan
Disoprofol, Propofol, AM-149(New formulation), ZD-0859, ICI-35868, Ampofol, Propofol IDD-D, Disoprivan, Diprivan
丙泊酚Chemical Name: 2,6-Bis(1-methylethyl)phenol
CAS No. 2078-54-8
项目整合开发状态: Launched-1986
项目研究机构: AstraZeneca (Originator), Endo (Licensee), RTP Pharma (Licensee), Sicor (Generic), Manhattan Pharmaceuticals (Formulation), NovaDel Pharma (Formulation), SkyePharma (Formulation)
合成路线:By condensation of phenol (I) with propylene (II) at temperatures ranging from 230 C to 275 C and pressures up to 3000 atm.in an autoclave,using aluminum phenoxide as catalyst.
📌 参考资料/链接：
参考文献标题:Disoprofol
文献作者:Serradell,M.N.; Castar,J.; Sneddon,J.M.; Blancafort,P.
参考来源:Drugs Fut 1982,7(3),156
📄 详细内容
合成路线:By condensation of phenol (I) with propylene (II) at temperatures ranging from 230 C to 275 C and pressures up to 3000 atm.in an autoclave,using aluminum phenoxide as catalyst.
参考文献标题:The ortho-alkylation of phenols
文献作者:Napolitano,J.P.; Ecke,G.G.; Kolka,A.J.
参考来源:J Org Chem 1956,21712-713
合成路线:By condensation of phenol (I) with propylene (II) at temperatures ranging from 230 C to 275 C and pressures up to 3000 atm.in an autoclave,using aluminum phenoxide as catalyst.
参考文献标题:The ortho-alkylation of phenols
文献作者:Ecke,G.G.; Kolka,A.J.; Napolitano,J.P.; Filbey,A.H.
参考来源:J Org Chem 1957,22642-646
合成路线:By condensation of phenol (I) with propylene (II) at temperatures ranging from 230 C to 275 C and pressures up to 3000 atm.in an autoclave,using aluminum phenoxide as catalyst.
参考文献标题:Thermal addition reactions of monocyclic phenols with ethylene
文献作者:Kealy,T.J.; Coffman,D.D.
参考来源:J Org Chem 1961,26987-992
产品链接: CAS No. 2078-54-8››