Valrocemide, TVP-1901, TV-1901
丙戊塞胺Chemical Name: N2-(2-Propylpentanoyl)glycinamide; N-Valproylglycinamide
CAS No. 92262-58-3
项目整合开发状态: Phase II
项目研究机构: Hebrew University (Originator), Yissum (Originator), Teva (Licensee), Acorda (Codevelopment), Teva (Codevelopment)
合成路线:The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.
📌 参考资料/链接：
参考文献标题:Derivs.of valproic and 2-valproenoic acid amides and use as anticonvulsants
文献作者:Bialer,M.; Hadad,S.; Herzig,J.; Sterling,J.; Lerner,D.; Shirvan,M.(Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.)
参考来源:EP 0659174; JP 1996504831; US 5585358; WO 9501956
📄 详细内容
合成路线:The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.
参考文献标题:Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine
文献作者:Hadad,S.; Bialer,M.
参考来源:Pharm Res 1995,12(6),905
产品链接: CAS No. 92262-58-3››