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项目整合精选>>>Probucol, DE-3872, DH-581, Lurselle, Sinlestal, Panavir(substained release), Lorelco
Probucol, DE-3872, DH-581, Lurselle, Sinlestal, Panavir(substained release), Lorelco
丙丁酚Chemical Name: 4,4'-[(Isopropylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl)mercaptole; 4,4'-(Isopropylidendithio)bis(2,6-di-tert-butylphenol)
CAS No. 23288-49-5
项目整合开发状态: Launched-1977
项目研究机构: Aventis Pharma (Originator), Cassenne (Not Determined), Daiichi Pharmaceutical (Licensee), Vyrex (Licensee)
合成路线:By condensation of 2,6-ditertbutyl-4-mercaptophenol (I) with acetone (II) in refluxing methanol with a catalytic amount of HCl.
📌 参考资料/链接：
参考文献标题:Probucol
文献作者:Castar,J.; Chatterjee,S.S.
参考来源:Drugs Fut 1977,2(2),128
📄 详细内容
合成路线:By condensation of 2,6-ditertbutyl-4-mercaptophenol (I) with acetone (II) in refluxing methanol with a catalytic amount of HCl.
参考文献标题:Method of lowering serum cholesterol
文献作者:Barnhart,J.W.; Shea,P.J.
参考来源:US 3862332
产品链接: CAS No. 23288-49-5››