Clevidipine, Clevelox
丁酸氯维地平 氯维地平 Chemical Name: (?-4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid butyryloxymethyl methyl diester
CAS No. 167221-71-8, 166432-28-6 (deleted CAS)
项目整合开发状态: Phase III
项目研究机构: AstraZeneca (Originator), The Medicines Co. (Licensee)
合成路线:Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).
📌 参考资料/链接：
参考文献标题:Short-acting dihydropyridines
文献作者:Andersson,K.H.; Nordlander,M.; Westerlund,R.C.(AstraZeneca plc)
参考来源:EP 0726894; JP 1997504542; US 5856346; WO 9512578
📄 详细内容
合成路线:Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).
参考文献标题:New manufacturing process
文献作者:Mattson,A.; Svensson,C.; Thnblom,K.; 謉man,C.(AstraZeneca AB)
参考来源:CA 2349195; EP 1133473; US 6350877; WO 0031035
合成路线:Clevidipine is prepared by esterification of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (I) with chloromethyl butyrate (II) by means of NaHCO3 in DMF at 80 oC (1) or refluxing acetonitrile (2).
参考文献标题:Clevidipine
文献作者:Sorbera,L.A.; Castar,J.
参考来源:Drugs Fut 2004,29(2),105
产品链接: CAS No. 167221-71-8›› 产品链接: CAS No.166432-28-6››