Flavodilol maleate, PR-87730L
丁-2-烯二酸:7-(2-羟基-3-丙基氨基丙氧基)-2-苯基苯并吡喃-4-酮 黄酮地洛 Chemical Name: (?-7-[2-Hydroxy-3-(propylamino)propoxy]-2-phenyl-4H-1-benzopyran-4-one (Z)-2-butenedioate (1:1) (salt); (?-7-(2-Hydroxy-3-(propylamino)propoxy]flavone maleate (1:1) (salt)
CAS No. 79619-32-2, 79619-31-1 (free base)
项目整合开发状态: Preclinical
项目研究机构: Pennwalt (Originator)
合成路线:The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III),which is then treated with propylamine (IV) in methanol,and neutralized with maleic acid.
📌 参考资料/链接：
参考文献标题:Antihypertensive agents
文献作者:Wu,E.S.-C.(Pennwalt Corp.)
参考来源:EP 0064165; US 4501755
📄 详细内容
合成路线:The condensation of epichlorohydrin (I) with 7-hydroxyflavone (II) by means of NaOH in ethanol - water gives 7-(2,3-epoxypropoxy)fIavone (III),which is then treated with propylamine (IV) in methanol,and neutralized with maleic acid.
参考文献标题:Flavodilol maleate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(10),837
产品链接: CAS No. 79619-32-2›› 产品链接: CAS No.79619-31-1››