YM-90K, YM-900(free base)
YM 90K盐酸盐 2,3-喹诺沙林地酮,1,4-二氢-6-(1H-吡达唑-1-基)-7-硝基- Chemical Name: 6-(1-Imidazolyl)-7-nitroquinoxaline-2,3-(1H,4H)-dione monohydrochloride
CAS No. 154164-30-4, 143151-35-3 (free base), 157971-78-3 (YM-900)
项目整合开发状态: Phase II
项目研究机构: Yamanouchi (Originator)
合成路线:The condensation of 5-chloro-2-nitroaniline (I) with imidazole (II) by means of KOH in DMSO gives 5-(1-imidazolyl)-2-nitroaniline (III).Hydrogenation of (III) over Pd/C in 1N HCl gives the diamine (IV),which is condensed with oxalic acid (V) in 4N HCl yielding 6-(1-imidazolyl)quinoxaline-2,3(1H,4H)-dione hydrochloride (VI).Finally,this compound is nitrated with HNO3/H2SO4.
📌 参考资料/链接：
参考文献标题:Imidazolylquinoxaline-2,3-diones: Novel and potent antagonists of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) excitatory amino acid receptor
文献作者:Sakamoto,S.; Ohmori,J.; Shimizu-Sasamata,M.; et al.
参考来源:12th Int Symp Med Chem (Sept 13-17,Basel) 1992,Abst P-022.A.
📄 详细内容
合成路线:The condensation of 5-chloro-2-nitroaniline (I) with imidazole (II) by means of KOH in DMSO gives 5-(1-imidazolyl)-2-nitroaniline (III).Hydrogenation of (III) over Pd/C in 1N HCl gives the diamine (IV),which is condensed with oxalic acid (V) in 4N HCl yielding 6-(1-imidazolyl)quinoxaline-2,3(1H,4H)-dione hydrochloride (VI).Finally,this compound is nitrated with HNO3/H2SO4.
参考文献标题:6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: Structure-activity relationships for the AMPA-type non-NMDA receptor
文献作者:Ohmori,J.; Sakamoto,S.; Kubota,H.; Shimizu-Sasamata,M.; Okada,M.; Kawasaki,S.; Hidaka,K.; Togami,J.; Furuya,T.; Murase,K.
参考来源:J Med Chem 1994,37(4),467-75
合成路线:The condensation of 5-chloro-2-nitroaniline (I) with imidazole (II) by means of KOH in DMSO gives 5-(1-imidazolyl)-2-nitroaniline (III).Hydrogenation of (III) over Pd/C in 1N HCl gives the diamine (IV),which is condensed with oxalic acid (V) in 4N HCl yielding 6-(1-imidazolyl)quinoxaline-2,3(1H,4H)-dione hydrochloride (VI).Finally,this compound is nitrated with HNO3/H2SO4.
参考文献标题:YM-900
文献作者:Ngo,J.; Rabasseda,X.; Castar,J.
参考来源:Drugs Fut 1997,22(3),256
产品链接: CAS No. 154164-30-4›› 产品链接: CAS No.143151-35-3››