SCH-79797

SCH 79797二盐酸盐Chemical Name: N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
CAS No. 245520-69-8
项目整合开发状态: Biological Testing
项目研究机构: Schering-Plough (Originator)
合成路线:Alkylation of 5-nitroindole (I) with 4-isopropylbenzyl chloride (II) in the presence of Cs2CO3 provided the N-benzylindole derivative (III).Reduction of the nitro group of (III) by hydrogenation over Pd/C gave the corresponding amine,which was isolated as the hydrochloride salt (IV).The required pyrroloquinazoline system (V) was then prepared by reaction of (IV) with trichloromethyl isocyanate,followed by treatment with POCl3.Displacement of the 1-chlorine of (V) by ammonia afforded amine (VI).The remaining 3-chlorine of (VI) was then displaced by cyclopropylamine (VII) to furnish the title compound.