Cloturin, VUFB-15686
S-(7H-嘌呤-6-基)(2-氯乙基氨基)硫代甲酸酯Chemical Name: N-(2-Chloroethyl)thiocarbamic acid 6-purinyl ester; 6-[N-(2-Chloroethyl)carbamoyl]thiopurine; (2-Chloroethyl)carbamothioic acid S-1H-purin-6-yl ester
CAS No. 104789-46-0, 116861-52-0 ([35S]-labeled)
项目整合开发状态: Phase II
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Originator), SPOFA (Originator)
合成路线:The compound can be prepared by reacting mercaptopurine (I) with 2-chloroethylisocyanate (II) in an inert medium at a temperature from 0-50 C,preferably in the presence of an alkaline agent.Suitable inert media for the reaction are dimethylformamide,dimethylsulfoxide,phosphoric acid,hexamethyltriamide or tetramethylurea.Alkaline agents,preferably tertiary organic amines,accelerate the reaction and make the yield of the desired product higher.
📌 参考资料/链接：
参考文献标题:6-Purinyl N-(2-chloroethyl)carbamate and thiocarbamate,a process for their preparation and use thereof.CS 249576
文献作者:Cerny,A.; Krepelka,J.I.; Melka,M.; Molko,M.; Pokorn? S.; Reichov? R.; Kejhov? I.; Beitov? M.; Grimov? J.(SPOFA - United Pharmaceutical Works)
参考来源:EP 0186454; JP 1986186382; US 4720497
📄 详细内容
合成路线:The compound can be prepared by reacting mercaptopurine (I) with 2-chloroethylisocyanate (II) in an inert medium at a temperature from 0-50 C,preferably in the presence of an alkaline agent.Suitable inert media for the reaction are dimethylformamide,dimethylsulfoxide,phosphoric acid,hexamethyltriamide or tetramethylurea.Alkaline agents,preferably tertiary organic amines,accelerate the reaction and make the yield of the desired product higher.
参考文献标题:CLOTURIN
文献作者:Melka,M.; Krepelka,J.; Miko,M.
参考来源:Drugs Fut 1990,15(4),337
产品链接: CAS No. 104789-46-0››