Etintidine hydrochloride, BL-5641A
N-氰基-N'-[2-[[(5-甲基-1H-咪唑-4-基)甲基]硫代]乙基]-N''-2-丙炔基胍盐酸盐 依汀替丁 Chemical Name: 2-Cyano-1-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]-3-(2-propynyl)guanidine hydrochloride; N-Cyano-N'-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]-N''-propargylguanidine hydrochloride
CAS No. 71807-56-2, 69539-53-3 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:By condensation of N-cyano-N'-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]-S-methylisothiourea (I) with propargylamine (II) in refluxing acetonitrile.
合成路线:The reaction of propargylamine (II) with dimethyl cyanoiminodithiocarbonate (III) in refluxing acetonitrile gives N-cyano-N'-propargyl-S-methylisothiourea (IV),which is then condensed with 2-[(5-methyl-4-imidazolyl)methylthio]ethylamine (V) in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Imidazolylmethylthioethyl alkynyl guanidines
文献作者:Crenshaw,R.R.; Luke,G.M.(Bristol-Myers Squibb Co.)
参考来源:US 4112234
📄 详细内容
合成路线:By condensation of N-cyano-N'-[2-[(5-methyl-4-imidazolyl)methylthio]ethyl]-S-methylisothiourea (I) with propargylamine (II) in refluxing acetonitrile.
合成路线:The reaction of propargylamine (II) with dimethyl cyanoiminodithiocarbonate (III) in refluxing acetonitrile gives N-cyano-N'-propargyl-S-methylisothiourea (IV),which is then condensed with 2-[(5-methyl-4-imidazolyl)methylthio]ethylamine (V) in refluxing methanol.
参考文献标题:Etintidine hydrochloride
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1982,7(10),732
产品链接: CAS No. 71807-56-2›› 产品链接: CAS No.69539-53-3››