PNU-83757, U-83757, P-1075

N-氰基-N'-(1,1-二甲基丙基)-N''-3-吡啶基胍Chemical Name: 1-Cyano-2-(1,1-dimethylpropyl)-3-(3-pyridyl)guanidine
CAS No. 60559-98-0
项目整合开发状态: Phase II
项目研究机构: Leo (Originator), Pfizer (Not Determined)
合成路线:This compound can be obtained in two related ways:1) By reaction of N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)thiourea (I) with cyanamide (II) by means of dicyclohexylcarbodiimide (DCC) and ethyldiisopropylamine in ether.2) The reaction of (I) with phosgene in toluene - THF by means of ethyldiisopropylamine in THF gives N-(4-pyridyl)-N'-(1,2,2-trimethylpropyl)carbodiimide (III),which is condensed with (II) by means of ethyldiisopropylamine.

合成路线:Thiourea (III) was prepared by condensation of 3-pyridyl isothiocyanate (I) with 1,1-dimethylpropyl amine (II).Desulfuration of thiourea (III) by means of phosgene and diisopropyl ethylamine,or triphenylphosphine and CCl4 gave rise to the carbodiimide (IV).Finally,addition of cyanamide to carbodiimide (IV) furnished the target N-cyanoguanidine derivative