新产品编号:228317
N2-(顺-2-氨基环己基)-N6-(3-氯苯基)-9-乙基-9H-嘌呤-2,6-二胺Chemical Name: N2-(cis-2-Aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine
CAS No. 190653-73-7, 190653-77-1 (trans-isomer)
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:Condensation of 2,6-dichloropurine (I) with 3-chloroaniline (II) in hot pentanol yielded the 6-anilino purine (III).This was then alkylated at the N-9 with iodoethane and K2CO3 to afford (IV).Finally,displacement of the 2-chloro of (IV) with cis-1,2-cyclohexanediamine (V) at 150 C furnished the title compound.
📌 参考资料/链接：
参考文献标题:Purine derivs.and processes for their preparation
文献作者:Capraro,H.-G.; Zimmermann,J.; Furet,P.; Peterli,P.(Novartis AG)
参考来源:JP 1999514336; WO 9716452
📄 详细内容
合成路线:Condensation of 2,6-dichloropurine (I) with 3-chloroaniline (II) in hot pentanol yielded the 6-anilino purine (III).This was then alkylated at the N-9 with iodoethane and K2CO3 to afford (IV).Finally,displacement of the 2-chloro of (IV) with cis-1,2-cyclohexanediamine (V) at 150 C furnished the title compound.
参考文献标题:2,6,9-Trisubstituted purines: Optimization towards highly potent and selective CDK1 inhibitors
文献作者:Imbach,P.; Capraro,H.G.; Furet,P.; Mett,H.; Meyer,T.; Zimmermann,J.
参考来源:Bioorg Med Chem Lett 1999,9(1),91
产品链接: CAS No. 190653-73-7››