DO-897, BP-4.897, BP-897

N-{4-4-(2-甲氧基苯基)哌嗪-1-yl丁基}萘-2-羧酰胺Chemical Name: N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]naphthalene-2-carboxamide
CAS No. 192384-87-5
项目整合开发状态: Phase I
项目研究机构: Bioprojet (Originator), INSERM (Originator)
合成路线:N-(2-Methoxyphenyl)piperazine (I) was alkylated with 4-bromobutyronitrile (II) to provide the 3-cyanopropylpiperazine (III).Subsequent reduction of the cyano group of (III) using LiAlH4 produced the primary amine (IV).The title amide was then obtained by condensation of (IV) with 2-naphthoic acid (V) after activation as the corresponding acid chloride with (COCl)2 or as the mixed anhydride with isobutyl chloroformate.