PD-176252

N-{[1-(5-甲氧基-2-吡啶基)环己基]甲基}-alpha-甲基-Nalpha-[(4-硝基苯基)氨基甲酰]-L-色氨酰胺Chemical Name: 3-(1H-Indol-3-yl)-N-[1-(5-methoxy-2-pyridinyl)cyclohexylmethyl]-2(S)-methyl-2-[3-(4-nitrophenyl)ureido]propionamide
CAS No. 204067-01-6
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Condensation of (S)-alpha-methyl tryptophan (I) with 4-nitrophenyl isocyanate (II) produced urea (III).This was then coupled to amine (IV) using HBTU to yield the target amide.