FTI-2148
N-[5-(1H-吡唑-4-甲基氨基甲基)-2'-甲基苯基-2-酰羰基]-L-甲硫氨酸Chemical Name: N-[5-(1H-Imidazol-4-ylmethylaminomethyl)-2'-methylbiphenyl-2-ylcarbonyl]-L-methionine
CAS No. 251577-09-0
项目整合开发状态: Preclinical
项目研究机构: H. Lee Moffitt Center (Originator), London School Hygiene Tropical Medicine (Originator), Seattle Biomedical Research Institute (Originator), University of Washington (Originator), Yale University (Originator)
合成路线:Reductive amination of the methionine methyl ester adduct of 2-(2-methylphenyl)-4-aminomethyl benzoic acid (I) with 1-trityl-4-formylimidazole (II) gave the secondary amine (III).After trityl group deprotection,the resultant methyl ester (IV) was hydrolyzed to the target carboxylic acid by using LiOH.
📌 参考资料/链接：
参考文献标题:Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin,Taxol,and gemcitabine
文献作者:Sun,J.; Blaskovich,M.A.; Knowles,D.; Qian,Y.; Ohkanda,J.; Bailey,R.D.; Hamilton,A.D.; Sebti,S.M.
参考来源:Cancer Res 1999,59(19),4919