OPC-21268
N-[3-[4-[[4-(3,4-二氢-2-氧代-1(2H)-喹啉基)-1-哌啶基]羰基]苯氧基]丙基]乙酰胺Chemical Name: 1-[1-[4-[3-(Acetylamino)propoxy]benzoyl]piperidin-4-yl]-1,2,3,4-tetrahydro-2-quinolinone; N-[3-[4-[4-(2-Oxo-1,2,3,4-tetrahydro-1-quinolinyl)piperidin-1-ylcarbonyl]phenoxy]propyl]acetamide
CAS No. 131631-89-5
项目整合开发状态: Phase II
项目研究机构: Otsuka (Originator)
合成路线:The reductocondensation of 3-(2-aminophenyl)propionamide (I) with 1-[4-(3-acetamidopropoxy)benzoyl]piperidin-4-one (II) by means of H2 and PtO2 in acetic acid gives 3-[2-[1-[4-(3-acetamidopropoxy)benzoyl]piperidin-4-ylamino]phenyl] propionamide (III),which is finally cyclized in refluxing 5% HCl.
📌 参考资料/链接：
参考文献标题:Carbostyril derivs
文献作者:Ogawa,H.; Miyamoto,H.; Kondo,K.; Yamashita,H.; Nakaya,K.; Tominaga,M.; Yabuuchi,Y.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0382185; JP 1991173870; US 5225402; US 5436256; US 5652247
📄 详细内容
合成路线:The reductocondensation of 3-(2-aminophenyl)propionamide (I) with 1-[4-(3-acetamidopropoxy)benzoyl]piperidin-4-one (II) by means of H2 and PtO2 in acetic acid gives 3-[2-[1-[4-(3-acetamidopropoxy)benzoyl]piperidin-4-ylamino]phenyl] propionamide (III),which is finally cyclized in refluxing 5% HCl.
参考文献标题:OPC-21268
文献作者:Mealy,N.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1993,18(10),901
产品链接: CAS No. 131631-89-5››