RU-24213
N-[2-(3-羟基苯基)乙基]-N-(2-苯乙基)丙基胺Chemical Name: N-[2-(3-Hydroxyphenyl)ethyl]-N-(2-phenylethyl)propylamine
CAS No. 315209-09-7, 67383-44-2 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of 3-methoxyphenylethylamine (I) with phenylethyl bromide (II) in refluxing triethylamine gives 3-methoxy-N-(phenylethyl)phenylethylamine (III),which is alkylated with 1-iodopropane by means of K2CO3 in refluxing acetone yielding 3-methoxy-N-propyl-N-(phenylethyl)phenylethylamine (IV).Finally,this compound is demethylated by treatment with refluxing aqueous 48% HBr and formation of the HCl salt with hydrochloric acid.
📌 参考资料/链接：
参考文献标题:Synthesis of study of the dopaminergic activity of di(phenylethyl)amine derivatives
文献作者:Nedelec,L.; et al.
参考来源:Eur J Med Chem - Chim Ther 1978,13(6),553-556
📄 详细内容
合成路线:The reaction of 3-methoxyphenylethylamine (I) with phenylethyl bromide (II) in refluxing triethylamine gives 3-methoxy-N-(phenylethyl)phenylethylamine (III),which is alkylated with 1-iodopropane by means of K2CO3 in refluxing acetone yielding 3-methoxy-N-propyl-N-(phenylethyl)phenylethylamine (IV).Finally,this compound is demethylated by treatment with refluxing aqueous 48% HBr and formation of the HCl salt with hydrochloric acid.
参考文献标题:RU-24213
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.; Owen,R.T.
参考来源:Drugs Fut 1981,6(4),237
产品链接: CAS No. 315209-09-7›› 产品链接: CAS No.67383-44-2››