YM-44778(fumarate salt (1:1))

N-[2-(3,4-二氯苯基)-4-[3-氧基-1,2,3,4-四氢螺蓄[异喹啉-1,4'-哌啶]-1'-基]丁基]-3,4,5-三甲氧基-N-甲基苯甲酰Chemical Name: N-[2-(3,4-Dichlorophenyl)-4-[3-oxo-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidin]-1'-yl]butyl]-3,4,5-trimethoxy-N-methylbenzamide
CAS No. 173941-74-7, 173941-75-8 (fumarate(1:1))
项目整合开发状态: Biological Testing
项目研究机构: Yamanouchi (Originator)
合成路线:The cyclization of cyanogen chloride (I) with aqueus methylamine (II) at 150 C in a pressure vessel gives N2,N4,N6-trimethylmelamine (III),which is then treated with aqueous formaldehyde at pH 8.9.

合成路线:Treatment of alcohol (I) with methanesulfonyl chloride in the presence of triethylamine provided mesylate (II),which was condensed with the spirosubstituted piperidine (III) to give the desired compound.