Thymectacin, NB-1011, NB-101
N-[[5-[(E)-2-溴乙烯基]-2'-脱氧尿苷-5'-O-基](苯氧基)磷酰]-L-丙氨酸甲酯Chemical Name: N-[[5-[(E)-2-Bromovinyl]-2'-deoxyuridin-5'-O-yl](phenoxy)phosphoryl]-L-alanine methyl ester
CAS No. 232925-18-7
项目整合开发状态: Phase I/II
项目研究机构: NewBiotics (Originator), Elan (Licensee)
合成路线:The title compound was synthesized by coupling 5-(bromovinyl)-2'-deoxyuridine (I) with phenyl L-methoxyalanino phosphoroamidate (II) in the presence of imidazole in DMF.
📌 参考资料/链接：
参考文献标题:Enzyme catalyzed therapeutic agents
文献作者:Shepard,H.M.(NewBiotics,Inc.)
参考来源:EP 1167972; JP 2001220397; US 6245750; WO 9937753
📄 详细内容
合成路线:The title compound was synthesized by coupling 5-(bromovinyl)-2'-deoxyuridine (I) with phenyl L-methoxyalanino phosphoroamidate (II) in the presence of imidazole in DMF.
参考文献标题:An improved procedure for the synthesis of nucleoside phosphoramidates
文献作者:Vaino,A.R.; Lobl,T.J.; Baehr,D.N.; Lehsten,D.M.
参考来源:Org Process Res Dev 2002,6(6),819
产品链接: CAS No. 232925-18-7››