D-threo-PDPP

N-[(1R,2R)-2-羟基-2-苯基-1-(1-吡咯烷甲基)乙基]-癸酰胺Chemical Name: (R,R)-N-[2-Hydroxy-2-phenyl-1-(1-pyrrolidinylmethyl)ethyl]decanamide
CAS No. 193545-89-0
项目整合开发状态: Biological Testing
项目研究机构: Seikagaku (Originator)
合成路线:(1R,2R)-2-Benzyloxycarbonylamino-1-phenyl-1,3-propanediol (I) was converted to mesylate (II) upon treatment with methanesulfonyl chloride in pyridine.Reaction of this mesylate with pyrrolidine (III) provided pyrrolidino compound (IV).The N-benzyloxycarbonyl group of (IV) was then eliminated by hydrogenolysis over Pd/C to yield the vicinal hydroxyamine (V),which was finally condensed with decanoyl chloride (VI) to furnish the target decanoyl amide.