EUK-189
N,N'-双(3-乙氧基亚水杨基)-1,2-乙二胺-锰(II)Chemical Name: (SP-5-13)-(Acetato-kappaO)[[2,2'-[1,2-ethanediylbis[(nitrilo-kappaN)methylidyne]]bis[6-ethoxyphenolato-kappaO1]](2-)]manganese
CAS No. 186350-27-6
项目整合开发状态: Preclinical
项目研究机构: Eukarion (Originator)
合成路线:Condensation of the salicylaldehyde derivative (I) with ethylenediamine (II) affords the bis-imine (III).The title manganese complex is then obtained by treatment of (III) with manganese diacetate in ethanol.
📌 参考资料/链接：
参考文献标题:Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
文献作者:Malfroy-Camine,B.; Doctrow,S.R.(Eukarion,Inc.)
参考来源:JP 1999507646; US 5696109; WO 9640148; WO 9640149
📄 详细内容
合成路线:Condensation of the salicylaldehyde derivative (I) with ethylenediamine (II) affords the bis-imine (III).The title manganese complex is then obtained by treatment of (III) with manganese diacetate in ethanol.
参考文献标题:Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies
文献作者:Marcus,C.B.; Huffman,K.; Doctrow,S.R.; Tocco,G.; Malfroy,E.; Adinolfi,C.A.; Kruk,H.; Baker,K.; Lazarowych,N.; Mascarenhas,J.; Malfroy,B.
参考来源:J Med Chem 2002,45(20),4549
产品链接: CAS No. 186350-27-6››