Deramciclane fumarate, EGIS-3886, EGYT-3886

N,N-二甲基-2-[[(1R,2R,4R)-1,7,7-三甲基-2-苯基二环[2.2.1]庚-2-基]氧基]乙胺富马酸盐 德伦环烷Chemical Name: (1R,2S,4R)-(-)-N,N-Dimethyl-2-[(1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl)oxy]ethanamine 2(E)-butenedioate (1:1); (1R,2S,4R)-(-)-2-(Dimethylaminoethoxy)-2-phenyl-1,7,7-trimethylbicyclo[2.2.1]heptane 2(E)-butenedioate (1:1); N,N-Dimethyl-2-[[(1R,2S,4R)-2-phenyl-2-bornyl]oxy]ethylamine monofumarate
CAS No. 120444-74-8, 80178-61-6 (exo-phenyl isomer), 120444-71-5 (free base)
项目整合开发状态: Discontinued
项目研究机构: Egis (Originator), Orion Corp. (Licensee), Pfizer (Codevelopment)
合成路线:Grignard addition of phenylmagnesium bromide to (+)-camphor (I) yielded the endo-alcohol (II),which was reacted with 1-dimethylamino-2-chloroethane (III) to give the base corresponding to EGYT-3886.EGYT-3886 is the 2-(E)-butenedioate salt (1:1).