Flurofamide, EU-4534
N-(二氨基氧膦基)-4-氟苯甲酰胺Chemical Name: N-(4-Fluorobenzoyl)phosphorotriamide; N-(Diaminophosphinyl)-4-fluorobenzamide
CAS No. 70788-28-2
项目整合开发状态: Preclinical
项目研究机构: Norwich Eaton (Originator)
合成路线:The reaction of p-fluorobenzamide (I) with phosphorus pentachloride (II) in refluxing CCl4,followed by a treatment with formic acid gives N-(dichlorophosphinyl)-p-fluorobenzamide (III),which is then treated with NH3 in CHCl3.
📌 参考资料/链接：
参考文献标题:N-[Diaminophosphinyl]arylcarboxamides
文献作者:Bayless,A.V.; Millner,O.E.Jr.(Norwich Eaton)
参考来源:US 4182881
📄 详细内容
合成路线:The reaction of p-fluorobenzamide (I) with phosphorus pentachloride (II) in refluxing CCl4,followed by a treatment with formic acid gives N-(dichlorophosphinyl)-p-fluorobenzamide (III),which is then treated with NH3 in CHCl3.
参考文献标题:Flurofamide
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(10),734
产品链接: CAS No. 70788-28-2››