Talosalate, BA-760402

他洛柳酯Chemical Name: 1,3-Dihydro-3-oxo-1-isobenzofuranyl 2-acetyloxybenzoate
CAS No. 66898-60-0
项目整合开发状态: Preclinical
项目研究机构: Bag?(Originator)
合成路线:1) The reaction of 3-bromophthalide with 2-hydroxybenzoic acid (I),previously salified with triethylamine in refluxing acetone gives 1,3-dihydro-3-oxo-1-isobenzofuranyl 2-hydroxybenzoate (II).Compound (II) is acetylated with acetic anhydride,using sulfuric acid as catalizer.
📌 参考资料/链接:
参考文献标题:Nouveaux esters de l'acide benzoique substitue
文献作者:(Laboratorios Bag?
参考来源:BE 0884978

📄 详细内容


合成路线:2) By condensation of an organic salt of 2-acetyloxybenzoic acid (III) with 3-bromophthalide.

参考文献标题:Methods of treating mammals suffering from inflammation and pain
文献作者:Los,M.A.(Laboratorios Bag?
参考来源:BE 0858864; JP 8162049; US 4256760


合成路线:1) The reaction of 3-bromophthalide with 2-hydroxybenzoic acid (I),previously salified with triethylamine in refluxing acetone gives 1,3-dihydro-3-oxo-1-isobenzofuranyl 2-hydroxybenzoate (II).Compound (II) is acetylated with acetic anhydride,using sulfuric acid as catalizer.

合成路线:2) By condensation of an organic salt of 2-acetyloxybenzoic acid (III) with 3-bromophthalide.
参考文献标题:Talosalate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(5),394


产品链接: CAS No. 66898-60-0››