Bucladesine sodium, DT-5621, DBcAMP.Na, Actosin
二丁酰环磷腺苷钙 二丁酰环磷腺苷钠Chemical Name: N-(1-Oxobutyl)adenosine cyclic 3',5'-(hydrogen phosphate) 2'-butanoate sodium salt
CAS No. 19436-29-4, 362-74-3 (free acid), 16980-89-5 (monoNa salt)
项目整合开发状态: Launched-1985
项目研究机构: Daiichi Pharmaceutical (Originator)
合成路线:The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III),which is then treated with Na-type Amberlite IR-120 B.
📌 参考资料/链接：
参考文献标题:Bucladesine Sodium
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(2),106
📄 详细内容
合成路线:The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III),which is then treated with Na-type Amberlite IR-120 B.
参考文献标题:Improved methods of producing adenosine derivatives
文献作者:Hirayama,T.; et al.
参考来源:JP 52039699
合成路线:The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III),which is then treated with Na-type Amberlite IR-120 B.
合成路线:The reaction of 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (I) with 4-aminopyridine (II) gives the corresponding pyridinium salt (III),which is reduced with NaBH4 to 2-[3-(4-aminopiperidyl)propyl]-2-(4-fluorophenyl)-1,3-dioxolane (IV).The condensation of (IV) with 2-chloronitrobenzene (V) yields 2-[3-[4-(2-nitroanilino)piperidyl]propyl]-2-(4-fluorophenyl)-1,3-dioxolane (VI),which is hydrogenated with H2 over Raney-Ni affording the corresponding amino compound (VII).Finally this compound is cyclized with carbon disulfide and KOH
合成路线:The reaction of o-phenylenediamine (IX) with 4-chloropyridine (VIII) gives 2-(4-pyridylamino)aniline (X),which is condensed with 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (I) to give the corresponding pyridinium salt (XI).The reduction of (XI) with NaBH4 yields amino compound (VII).Finally this compound is cyclized with carbon disulfide and KOH
参考文献标题:
文献作者:
参考来源:JP 76095096
合成路线:The reaction of adenosine-3',5'-cyclic phosphate (I) with butyric anhydride (II) in the presence of triethylamine gives N6,2'-O-dibutyryladenosine-3',5'-cyclic phosphate (III),which is then treated with Na-type Amberlite IR-120 B.
参考文献标题:
文献作者:
参考来源:JP 76113896